Endocrine Abstracts

Background: Hyponatremia (HN) is the most common electrolyte disorder of hospitalized patients. It occurs in up to 28% of in-patients, is more common in the elderly and patients with multiple co-morbidities, increases the in-hospital risk of death by 1.47-fold, and is associated with significantly higher mortality risk following discharge. The HN Registry is the first large-scale, international effort to document the clinical characteristics, choice of therapies, and impact of...

Hyponatraemia is the most common fluid and electrolyte disorder encountered in clinical medicine, with incidences as high as 15% to 30% in both acutely and chronically hospitalized patients. Differential diagnosis is complicated by a long list of potential etiologies. Traditional diagnostic strategies entail an initial characterization of the patient's extracellular fluid volume status to differentiate euvolemic hyponatraemia from hypovolemic hyponatraemia (generally indicatin...

Hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and disorders such as congestive heart failure and cirrhosis represents a common problem often encountered in the care of medical patients. Available treatment modalities for disorders of excess arginine vasopressin (AVP) secretion, or action, include fluid restriction, demeclocycline and NaCl administration, but all of these therapies have significant drawbacks and are suboptimal. Over th...

Background: Hyponatraemia (HN) is the most common electrolyte disorder of hospitalised patients with a frequency approximating 15%. HN is associated with multiple co-morbidities as well as increases in length of stay (LOS), rehospitalisation, cardiovascular events, and death. This novel HN registry represents the first large-scale international effort to document the impact of HN on clinically relevant outcomes.Methods: The HN registry is an ongoing, glo...